Optimisation and Development of the Peel-off Gel Formulation for the Decontamination of Radiological Contaminants from Skin

In the present work, an effective and systematic modelling technique is devised to generate optimal formulations for explicit polymer film applications. These methods aim at developing quantitative values for not only intrinsic properties, but qualitative characteristics are developed in order to simultaneously optimise the formulation subject to the specific radio-contaminants decontamination. The predictive modelling framework developed is comprised of a) polymer optimisation, b) film forming property, c) peel-off the film, d) constraint parameters, e) constitutive equations design/optimisation variables and f) development the peel-off gel formulation (El‐Halwagi et al., 2004; Eden et al., 2004; Ponce-Ortega et al., 2010). A set of user defined design constraints produces a subset of different optimisation formulations comprised of different polymer blends, molecular weights, hydrolysation extents, solvents, and additives. This contribution illustrates a novel way to evaluate a wide range of polymeric film compounds and mixtures with fewer testing interactions. Peel-off gel formulation developed is suited for the application over the open and exposed parts of the body. Gels due to vast network have comparatively better loading capacity with least leakage problem. It also has the good stability comparatively with other drug dosages form and does not associated with breaking and rancidity problems. Hence formulation was developed for the skin decontamination for localised radiological decontaminants.